CETUXIMAB IN COMBINATION WITH IRINOTECAN/5-FLUOROURACIL/FOLINIC ACID (FOLFIRI) IN THE INITIAL TREATMENT OF METASTATIC COLORECTAL CANCER: A MULTICENTRE TWO-PART PHASE I/II STUDY

Abstract Background This study was designed to investigate the efficacy and safety of the epidermal growth factor receptor (EGFR) inhibitor cetuximab combined with irinotecan, folinic acid (FA) and two different doses of infusional 5-fluorouracil (5-FU) VL Series Parts in the first-line treatment of EGFR-detectable metastatic colorectal cancer.Meth

Spent broiler hen meat is sold at a lower price, owing to its poor texture and lower acceptability, in WASH BRUSH comparison with broiler meat.The tenderization of spent hen meat using kiwi and pineapple extracts will encourage meat processors to use this less expensive meat as a new source of raw materials for the production of different chicken m

Accurately measuring vehicle mileage is pivotal in precise CO2 emission calculations and the development of reliable emission models.Nonetheless, mileage data gathered from surveys relying on self-estimation, garage reports, and other estimation-based sources often yield rough approximations that substantially deviate from the actual mileage.To tac

Many Calderonian characters find difficult to keep a secret against the human tendency to complaints WASH BRUSH and release, as well as external pressures that influence their revelation.Among the many expressions referring to this struggle between contentio and overflow highlights in a special way the volcanic metaphor because of its proliferation